In 2009, Adrian Helmsley (Chiwetel Ejiofor), an American geologist, visits astrophysicist Dr. Satnam Tsurutani (Jimi Mistry) in India and learns that neutrinos from a massive solar flare are causing the temperature of the Earth's core to increase. Adrian informs White House Chief of Staff Carl Anheuser (Oliver Platt) and United States President Thomas Wilson (Danny Glover) that this will trigger a catastrophic chain of natural disasters.
In 2010, Wilson, along with other international leaders, begins a secret project intended to ensure humanity's survival. Approximately 400,000 people are chosen to board ships called "arks" that are constructed at Cho Ming, Tibet, in the Himalayas. Additional funding for the project is raised by selling tickets to the private sector for €1 billion per person.By 2011, humanity's valuable treasures are moved to the Himalayas under the guise of protecting them from terrorist attacks with the help of art expert/First Daughter Dr. Laura Wilson (Thandie Newton) when she meets with the Louvre director Roland Picard (Patrick Bauchau).
In 2012, Jackson Curtis (John Cusack) is a science fiction writer in Los Angeles who works part-time as a limousine driver for billionaire Yuri Karpov (Zlatko Burić). Jackson's ex-wife Kate (Amanda Peet) and their children Noah (Liam James) and Lilly (Morgan Lily) live with Kate's boyfriend, plastic surgeon and amateur pilot Gordon Silberman (Thomas McCarthy).